Hepatocellular carcinoma (HCC) is one of the few cancers in which a continued increase in incidence has been observed over recent years. Globally, there are approximately 750,000 new cases of liver cancer reported each year. Importantly, population-based studies show that HCC ranks as the third leading cause of cancer-related deaths worldwide. Also, a large proportion of HCC patients display symptoms of intrahepatic metastases or postsurgical recurrence, with a five-year survival rate of around only 30-40%.
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