Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and is associated with exposure to hepatitis B virus (HBV). Patients carrying the virus have a 100-fold greater risk of developing HCC, but exactly why was unclear until now. Wing Kin Sung at the A*STAR Genome Institute of Singapore and the National University of Singapore, John Luk at the A*STAR Institute of Molecular and Cell Biology and the National University of Singapore and co-workers have now identified genetic mechanisms by which a virus contributes to this common form of cancer.
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